产品内容
本酶催化的反应为A [Histone H3]-N6,N6,N6-Trimethyl-L-Lysine4 + 3 2-Oxoglutarate + 3 O2 = A [Histone H3]-L-Lysine4 + 3 Succinate + 3 Formaldehyde + 3 CO2 (Overall Reaction);;(1a) A [Histone H3]-N6,N6,N6-Trimethyl-L-Lysine4 + 2-Oxoglutarate + O2 = A [Histone H3]-N6,N6-Dimethyl-L-Lysine4 + Succinate + Formaldehyde + CO2;;(1b) A [Histone H3]-N6,N6-Dimethyl-L-Lysine4 + 2-Oxoglutarate + O2 = A [Histone H3]-N6-Methyl-L-Lysine4 + Succinate + Formaldehyde + CO2;;(1c) A [Histone H3]-N6-Methyl-L-Lysine4 + 2-Oxoglutarate + O2 = A [Histone H3]-L-Lysine4 + Succinate + Formaldehyde + CO2,系统名称为[Histone H3]-N6,N6,N6-Trimethyl-L-Lysine4,2-Oxoglutarate:oxygen Oxidoreductase,需要铁(II)。该条目描述一组使组蛋白 H3 第 4 位 N-甲基化 L-赖氨酸残基(H3K4)脱甲基的酶。这些酶是双加氧酶,通过羟化甲基起作用,形成不稳定的半缩醛胺,以甲醛形式离去。它们可以作用于三、二和单甲基化形式。