产品内容
本酶催化的反应为A [Histone H3]-N6,N6,N6-Trimethyl-L-Lysine27 + 2 2-Oxoglutarate + 2 O2 = A [Histone H3]-N6-Methyl-L-Lysine27 + 2 Succinate + 2 Formaldehyde + 2 CO2 (Overall Reaction);;(1a) A [Histone H3]-N6,N6,N6-Trimethyl-L-Lysine27 + 2-Oxoglutarate + O2 = A [Histone H3]-N6,N6-Dimethyl-L-Lysine27 + Succinate + Formaldehyde + CO2;;(1b) A [Histone H3]-N6,N6-Dimethyl-L-Lysine27 + 2-Oxoglutarate + O2 = A [Histone H3]-N6-Methyl-L-Lysine27 + Succinate + Formaldehyde + CO2,系统名称为[Histone H3]-N6,N6,N6-Trimethyl-L-Lysine27,2-Oxoglutarate:oxygen Oxidoreductase,需要铁(II)。该条目描述一组使组蛋白 H3 第 27 位 N-甲基化 L-赖氨酸残基(H3K27)脱甲基的酶。这些酶是双加氧酶,通过羟化甲基起作用,形成不稳定的半缩醛胺,以甲醛形式离去。它们可以作用于三甲基化和二甲基化形式,但对单甲基化形式没有活性。