产品内容
本酶催化的反应为(+)-Epi-Isozizaene + 2 NADPH + 2 H+ + 2 O2 = Albaflavenone + 2 NADP+ + 3 H2O (Overall Reaction);;(1a) (+)-Epi-Isozizaene + NADPH + H+ + O2 = (5S)-Albaflavenol + NADP+ + H2O;;(1b) (5S)-Albaflavenol + NADPH + H+ + O2 = Albaflavenone + NADP+ + 2 H2O;;(2a) (+)-Epi-Isozizaene + NADPH + H+ + O2 = (5R)-Albaflavenol + NADP+ + H2O;;(2b) (5R)-Albaflavenol + NADPH + H+ + O2 = Albaflavenone + NADP+ + 2 H2O,系统名称为(+)-Epi-Isozizaene,NADPH:oxygen Oxidoreductase (5-Hydroxylating),这种来自土壤细菌天蓝色链霉菌 Streptomyces coelicolor A3(2) 的细胞色素 P-450 酶催化两个顺序的烯丙位氧化反应。底物表异橘烯(epi-isozizaene,由 EC 4.2.3.37 表异橘烯合酶的作用形成)首先被氧化,生成差向异构的中间体 (5R)-albaflavenol 和 (5S)-albaflavenol,后者可被进一步氧化,生成倍半萜类抗生素 albaflavenone。