产品内容
本酶催化的反应为5beta-Cholestane-3alpha,7alpha,12alpha-Triol + 3 NADPH + 3 H+ + 3 O2 = (25R)-3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholestan-26-Oate + 3 NADP+ + 4 H2O (Overall Reaction);;(1a) 5beta-Cholestane-3alpha,7alpha,12alpha-Triol + NADPH + H+ + O2 = (25R)-5beta-Cholestane-3alpha,7alpha,12alpha,26-Tetraol + NADP+ + H2O;;(1b) (25R)-5beta-Cholestane-3alpha,7alpha,12alpha,26-Tetraol + NADPH + H+ + O2 = (25R)-3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholestan-26-Al + NADP+ + 2 H2O;;(1c) (25R)-3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholestan-26-Al + NADPH + H+ + O2 = (25R)-3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholestan-26-Oate + NADP+ + H2O，系统名称为5beta-Cholestane-3alpha,7alpha,12alpha-Triol,NADPH:oxygen Oxidoreductase (26-Hydroxylating)，该酶需要铁氧还蛋白和铁氧还蛋白还原酶。它通过中性（经典）途径催化胆汁酸生物合成中前三个甾醇侧链氧化。也能作用于胆固醇、胆甾-5-烯-3β,7α-二醇、7α-羟基胆甾-4-烯-3-酮和5β-胆甾烷-3α,7α-二醇。该酶也能在24和25位羟基化胆固醇。
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