产品内容
本酶催化的反应为(1) 5beta-Cholestane-3alpha,7alpha-Diol + [Reduced NADPH---Hemoprotein Reductase] + O2 = 5beta-Cholestane-3alpha,7alpha,12alpha-Triol + [Oxidized NADPH---Hemoprotein Reductase] + H2O;; (2) 7alpha-Hydroxycholest-4-En-3-One + [Reduced NADPH---Hemoprotein Reductase] + O2 = 7alpha,12alpha-Dihydroxycholest-4-En-3-One + [Oxidized NADPH---Hemoprotein Reductase] + H2O;; (3) Chenodeoxycholate + [Reduced NADPH---Hemoprotein Reductase] + O2 = Cholate + [Oxidized NADPH---Hemoprotein Reductase] + H2O，系统名称为5beta-Cholestane-3alpha,7alpha-Diol,[reduced NADPH---Hemoprotein Reductase]:oxygen Oxidoreductase (12alpha-Hydroxylating)，一种存在于哺乳动物中的细胞色素 P-450（血红素-硫醇盐）蛋白。这是胆汁酸胆酸生物合成中的关键酶。该酶还可在 25 和 26 位羟基化 5beta-胆甾烷-3alpha,7alpha-二醇，但程度较轻 [2]。
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