产品内容
本酶催化的反应为(1) Testosterone + 3 O2 + 3 [Reduced NADPH---Hemoprotein Reductase] = 17beta-Estradiol + Formate + 4 H2O + 3 [Oxidized NADPH---Hemoprotein Reductase] (Overall Reaction);;(1a) Testosterone + O2 + [Reduced NADPH---Hemoprotein Reductase] = 19-Hydroxytestosterone + H2O + [Oxidized NADPH---Hemoprotein Reductase];;(1b) 19-Hydroxytestosterone + O2 + [Reduced NADPH---Hemoprotein Reductase] = 19-Oxotestosterone + 2 H2O + [Oxidized NADPH---Hemoprotein Reductase];;(1c) 19-Oxotestosterone + O2 + [Reduced NADPH---Hemoprotein Reductase] = 17beta-Estradiol + Formate + H2O + [Oxidized NADPH---Hemoprotein Reductase];;(2) Androst-4-Ene-3,17-Dione + 3 O2 + 3 [Reduced NADPH---Hemoprotein Reductase] = Estrone + Formate + 4 H2O + 3 [Oxidized NADPH---Hemoprotein Reductase] (Overall Reaction);;(2a) Androst-4-Ene-3,17-Dione + O2 + [Reduced NADPH---Hemoprotein Reductase] = 19-Hydroxyandrost-4-Ene-3,17-Dione + H2O + [Oxidized NADPH---Hemoprotein Reductase];;(2b) 19-Hydroxyandrost-4-Ene-3,17-Dione + O2 + [Reduced NADPH---Hemoprotein Reductase] = 19-Oxo-Androst-4-Ene-3,17-Dione + 2 H2O + [Oxidized NADPH---Hemoprotein Reductase];;(2c) 19-Oxoandrost-4-Ene-3,17-Dione + O2 + [Reduced NADPH---Hemoprotein Reductase] = Estrone + Formate + H2O + [Oxidized NADPH---Hemoprotein Reductase]，系统名称为Testosteronel,NADPH---Hemoprotein Reductase:oxygen Oxidoreductase (17beta-Estradiol-Forming)，一种细胞色素P-450。该酶催化雄激素雄甾-4-烯-3,17-二酮和睾酮的三次连续羟基化，使其芳构化，分别生成雌激素雌酮和17β-雌二醇。该酶的直接电子供体是 EC 1.6.2.4，NADPH---血红素蛋白还原酶。
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