产品内容
本酶催化的反应为Germacra-1(10),4,11(13)-Trien-12-Oate + [Reduced NADPH---Hemoprotein Reductase] + O2 = (+)-Costunolide + [Oxidized NADPH---Hemoprotein Reductase] + 2 H2O (Overall Reaction);;(1a) Germacra-1(10),4,11(13)-Trien-12-Oate + [Reduced NADPH---Hemoprotein Reductase] + O2 = 6alpha-Hydroxygermacra-1(10),4,11(13)-Trien-12-Oate + [Oxidized NADPH---Hemoprotein Reductase] + H2O;;(1b) 6alpha-Hydroxygermacra-1(10),4,11(13)-Trien-12-Oate = (+)-Costunolide + H2O (Spontaneous)，系统名称为Germacra-1(10),4,11(13)-Trien-12-Oate,[reduced NADPH---Hemoprotein Reductase]:oxygen Oxidoreductase (6alpha-Hydroxylating)，一种来自菊苣植物的细胞色素 P-450（血红素-硫醇盐）蛋白。该酶羟基化 germacra-1(10),4,11(13)-三烯-12-酸的 C-6 碳，生成 6alpha-羟基 germacra-1(10),4,11(13)-三烯-12-酸，后者自发环化形成内酯环。
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