产品内容
本酶催化的反应为(+)-Exo-beta-Bergamotene + 2 [Reduced NADPH---Hemoprotein Reductase] + 3 O2 = 5-Dehydro-6-Demethoxyfumagillol + 2 [Oxidized NADPH---Hemoprotein Reductase] + 3 H2O (Overall Reaction);;(1a) (+)-Exo-beta-Bergamotene + [Reduced NADPH---Hemoprotein Reductase] + O2 = (5R)-Hydroxy-(+)-Exo-beta-Bergamotene + [Oxidized NADPH---Hemoprotein Reductase] + H2O;;(1b) (5R)-Hydroxy-(+)-Exo-beta-Bergamotene + O2 = (3S)-3-[2-Methyl-3-(3-Methylbut-2-En-1-Yl)oxiran-2-Yl]-4-Methylidenecyclohexan-1-One + H2O;;(1c) (3S)-3-[2-Methyl-3-(3-Methylbut-2-En-1-Yl)oxiran-2-Yl]-4-Methylidenecyclohexan-1-One + [Reduced NADPH---Hemoprotein Reductase] + O2 = 5-Dehydro-6-Demethoxyfumagillol + [Oxidized NADPH---Hemoprotein Reductase] + H2O，系统名称为(+)-Exo-beta-Bergamotene,[reduced NADPH---Hemoprotein Reductase] Oxidoreductase (5-Dehydro-6-Demethoxyfumagillol-Producing)，该酶从霉菌烟曲霉（Aspergillus fumigatus）中鉴定，催化包括羟化、双环开环和两次环氧化在内的复杂转化，生成烟曲霉素（fumagillin）的倍半萜核心骨架。
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