产品内容
本酶催化的反应为5beta-Cholestane-3alpha,7alpha,12alpha-Triol + 6 Reduced Adrenodoxin + 6 H+ + 3 O2 = (25R)-3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholestan-26-Oate + 6 Oxidized Adrenodoxin + 4 H2O (Overall Reaction);;(1a) 5beta-Cholestane-3alpha,7alpha,12alpha-Triol + 2 Reduced Adrenodoxin + 2 H+ + O2 = (25R)-5beta-Cholestane-3alpha,7alpha,12alpha,26-Tetraol + 2 Oxidized Adrenodoxin + H2O;;(1b) (25R)-5beta-Cholestane-3alpha,7alpha,12alpha,26-Tetraol + 2 Reduced Adrenodoxin + 2 H+ + O2 = (25R)-3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholestan-26-Al + 2 Oxidized Adrenodoxin + 2 H2O;;(1c) (25R)-3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholestan-26-Al + 2 Reduced Adrenodoxin + 2 H+ + O2 = (25R)-3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholestan-26-Oate + 2 Oxidized Adrenodoxin + H2O，系统名称为5beta-Cholestane-3alpha,7alpha,12alpha-Triol,adrenodoxin:oxygen Oxidoreductase (26-Hydroxylating)，这种线粒体细胞色素P-450酶需要肾上腺皮质铁氧还蛋白。它催化经中性（经典）途径的胆汁酸生物合成中甾醇侧链的前三步氧化。也可作用于胆固醇、胆甾-5-烯-3β,7α-二醇、7α-羟基胆甾-4-烯-3-酮和5β-胆甾烷-3α,7α-二醇。该酶还能在24位和25位羟化胆固醇。电子最初来源于NADPH，后者经 EC 1.18.1.6，肾上腺皮质铁氧还蛋白-NADP+还原酶将电子转移给肾上腺皮质铁氧还蛋白。
暂无数据！
扫码关注公众号
