产品内容
本酶催化的反应为Luteothin + 2 O2 + 4 Reduced Ferredoxin [Iron-Sulfur] Cluster + 4 H+ = Aureothin + 3 H2O + 4 Oxidized Ferredoxin [Iron-Sulfur] Cluster (Overall Reaction);;(1a) Luteothin + O2 + 2 Reduced Ferredoxin [Iron-Sulfur] Cluster + 2 H+ = (7R)-7-Hydroxyluteothin + H2O + 2 Oxidized Ferredoxin [Iron-Sulfur] Cluster;;(1b) (7R)-7-Hydroxyluteothin + O2 + 2 Reduced Ferredoxin [Iron-Sulfur] Cluster + 2 H+ = Aureothin + 2 H2O + 2 Oxidized Ferredoxin [Iron-Sulfur] Cluster,系统名称为Luteothin,ferredoxin:oxygen Oxidoreductase (Aureothin-Forming),该酶源自硫藤黄链霉菌(Streptomyces thioluteus),是一种双功能细胞色素 P-450(血红素-硫醇盐)蛋白,既催化其底物的羟基化,又催化呋喃环的形成——这是抗生素金丝菌素(aureothin)生物合成的最后一步。在细菌 Streptomyces orinoci 和 Streptomyces spectabilis 中,一种直系同源酶催化类似反应,形成 spectinabilin。