产品内容
本酶催化的反应为(+)-Epi-Isozizaene + 4 Reduced [2Fe-2S] Ferredoxin + 4 H+ + 2 O2 = Albaflavenone + 4 Oxidized [2Fe-2S] Ferredoxin + 3 H2O (Overall Reaction);;(1a) (+)-Epi-Isozizaene + 2 Reduced [2Fe-2S] Ferredoxin + 2 H+ + O2 = (5S)-Albaflavenol + 2 Oxidized [2Fe-2S] Ferredoxin + H2O;;(1b) (5S)-Albaflavenol + 2 Reduced [2Fe-2S] Ferredoxin + 2 H+ + O2 = Albaflavenone + 2 Oxidized [2Fe-2S] Ferredoxin + 2 H2O;;(2a) (+)-Epi-Isozizaene + 2 Reduced [2Fe-2S] Ferredoxin + 2 H+ + O2 = (5R)-Albaflavenol + 2 Oxidized [2Fe-2S] Ferredoxin + H2O;;(2b) (5R)-Albaflavenol + 2 Reduced [2Fe-2S] Ferredoxin + 2 H+ + O2 = Albaflavenone + 2 Oxidized [2Fe-2S] Ferredoxin + 2 H2O，系统名称为(+)-Epi-Isozizaene,reduced-Ferredoxin:oxygen Oxidoreductase (5-Hydroxylating)，这种细胞色素 P-450 酶来自土壤细菌天蓝色链霉菌（Streptomyces coelicolor）A3(2)，催化两次连续的烯丙位氧化反应。底物表-异岩兰草烯（epi-isozizaene）由 EC 4.2.3.37（表-异岩兰草烯合酶）作用形成，首先被氧化生成差向异构中间体 (5R)-白黄素醇（albaflavenol）和 (5S)-白黄素醇，二者可被进一步氧化生成倍半萜类抗生素白黄素酮（albaflavenone）。
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