产品内容
本酶催化的反应为Cholesterol + 6 Reduced Adrenodoxin + 3 O2 + 6 H+ = Pregnenolone + 4-Methylpentanal + 6 Oxidized Adrenodoxin + 4 H2O (Overall Reaction);;(1a) Cholesterol + 2 Reduced Adrenodoxin + O2 + 2 H+ = (22R)-22-Hydroxycholesterol + 2 Oxidized Adrenodoxin + H2O;;(1b) (22R)-22-Hydroxycholesterol + 2 Reduced Adrenodoxin + O2 + 2 H+ = (20R,22R)-20,22-Dihydroxycholesterol + 2 Oxidized Adrenodoxin + H2O;;(1c) (20R,22R)-20,22-Dihydroxy-Cholesterol + 2 Reduced Adrenodoxin + O2 + 2 H+ = Pregnenolone + 4-Methylpentanal + 2 Oxidized Adrenodoxin + 2 H2O，系统名称为Cholesterol,reduced-Adrenodoxin:oxygen Oxidoreductase (Side-Chain-Cleaving)，一种血红素-硫醇盐蛋白（细胞色素P-450）。反应分三个阶段进行，C-22和C-20的两次羟基化先于20和22碳之间侧链的断裂。电子的初始来源是NADPH，它通过EC 1.18.1.6（肾上腺皮质铁氧还蛋白-NADP+还原酶）将电子转移给肾上腺皮质铁氧还蛋白（adrenodoxin）。
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