产品内容
本酶催化的反应为(1) 4-Hydroxybenzoate + 2 NADPH + 2 Bromide + 2 O2 + 2 H+ = 2,4-Dibromophenol + 2 NADP+ + CO2 + 4 H2O (Overall Reaction);;(1a) 4-Hydroxybenzoate + NADPH + Bromide + O2 + H+ = 3-Bromo-4-Hydroxybenzoate + NADP+ + 2 H2O;;(1b) 3-Bromo-4-Hydroxybenzoate + NADPH + Bromide + O2 + H+ = 2,4-Dibromophenol + NADP+ + CO2 + 2 H2O;;(2) 3,4-Dihydroxybenzoate + 2 NADPH + 2 Bromide + 2 O2 + 2 H+ = 3,5-Dibromobenzene-1,2-Diol + 2 NADP+ + CO2 + 4 H2O (Overall Reaction);;(2a) 3,4-Dihydroxybenzoate + NADPH + Bromide + O2 + H+ = 3-Bromo-4,5-Dihydroxybenzoate + NADP+ + 2 H2O;;(2b) 3-Bromo-4,5-Dihydroxybenzoate + NADPH + Bromide + O2 + H+ = 3,5-Dibromobenzene-1,2-Diol + NADP+ + CO2 + 2 H2O,系统名称为4-Hydroxybenzoate:NADPH Oxidoreductase (Brominating, Decarboxylating),含有 FAD。该酶见描述于交替假单胞菌(Pseudoalteromonas)和海单胞菌(Marinomonas)属的附生海洋细菌,是一种不寻常的单组分 FAD 依赖卤化酶,含有一个独立的 NAD(P)H 结合结构域,不需要额外的黄素还原酶即可发挥活性。该酶催化底物的一次溴化,随后进行与脱羧同步的第二次溴化。