产品内容
本酶催化的反应为(19E)-Geissoschizine + O2 + [Reduced NADPH-Hemoprotein Reductase] = Akuammicine + Formate + H2O + [Oxidized NADPH-Hemoprotein Reductase] (Overall Reaction);;(1a) (19E)-Geissoschizine + O2 + [Reduced NADPH-Hemoprotein Reductase] = 3,17-Didehydrostemmadenine + 2 H2O + [Oxidized NADPH-Hemoprotein Reductase];;(1b) 3,17-Didehydrostemmadenine = 17-Dehydropreakuammicine (Spontaneous);;(1c) 17-Dehydropreakuammicine + H2O = 17-Dehydropreakuammicine Hydrate (Spontaneous);;(1d) 17-Dehydropreakuammicine Hydrate = Akuammicine + Formate (Spontaneous)，系统名称为(19E)-Geissoschizine,[reduced NADPH-Hemoprotein Reductase]:oxygen Oxidoreductase (Akuammicine-Forming)，一种从植物 Catharanthus roseus（马达加斯加长春花）中鉴定的细胞色素 P-450（血红素-硫醇盐）酶，参与多种单萜生物碱以及双吲哚生物碱长春碱（vinblastine）和长春新碱（vincristine）的生物合成。该酶生成一个含氮原子的九碳环。该酶的直接产物 3,17-didehydrostemmadenine 不稳定，在没有其他酶的情况下非酶促地变成 akuammicine。然而，在两种脱氢酶存在下，它通过 17-dehydrostemmadenine 转化为 stemmadenine。
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