产品内容
本酶催化的反应为(1) ATP + A [Co(II) Methylamine-Specific Corrinoid Protein] + Reduced Acceptor + H2O = ADP + Phosphate + A [Co(I) Methylamine-Specific Corrinoid Protein] + Acceptor;;(2) ATP + A [Co(II) Dimethylamine-Specific Corrinoid Protein] + Reduced Acceptor + H2O = ADP + Phosphate + A [Co(I) Dimethylamine-Specific Corrinoid Protein] + Acceptor;;(3) ATP + A [Co(II) Trimethylamine-Specific Corrinoid Protein] + Reduced Acceptor + H2O = ADP + Phosphate + A [Co(I) Trimethylamine-Specific Corrinoid Protein] + Acceptor;;系统名称为Acceptor:[cobalt(II) Methylated Amines-Specific Corrinoid Protein] Oxidoreductase (ATP-Hydrolysing)，甲基营养型类咕啉蛋白必须处于活性钴(I)态才能被甲基化。由于钴(I)/钴(II)转变的氧化还原电位非常低，类咕啉辅因子容易发生偶然氧化至钴(II)态，使蛋白失活。该酶从产甲烷古菌巴氏甲烷八叠球菌（Methanosarcina barkeri）中鉴定，将钴(II)还原回钴(I)，恢复活性。该酶作用于参与由甲胺、二甲胺和三甲胺产甲烷的类咕啉蛋白，分别为 MtmC、MtbC 和 MttC。虽然体外该酶可以使用 Ti(III)-柠檬酸盐作为电子供体，但体内供体尚不清楚。来自巴氏甲烷八叠球菌的该酶含有一个 C 端 [4Fe-4S] 铁氧还蛋白样结构域。
![天净沙[Co(II)甲基化胺专一性类咕啉蛋白]还原酶活性测定试剂盒产品图片](https://www.tjs.bio/content/xtheme/tianjingsha/images/noimage.jpg)
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