产品内容
本酶催化的反应为(1) 3 S-Adenosyl-L-Methionine + N-Terminal-(A,S)PK-[Protein] = 3 S-Adenosyl-L-Homocysteine + N-Terminal-N,N,N-Trimethyl-N-(A,S)PK-[Protein] (Overall Reaction);;(1a) S-Adenosyl-L-Methionine + N-Terminal-(A,S)PK-[Protein] = S-Adenosyl-L-Homocysteine + N-Terminal-N-Methyl-N-(A,S)PK-[Protein];;(1b) S-Adenosyl-L-Methionine + N-Terminal-N-Methyl-N-(A,S)PK-[Protein] = S-Adenosyl-L-Homocysteine + N-Terminal-N,N-Dimethyl-N-(A,S)PK-[Protein];;(1c) S-Adenosyl-L-Methionine + N-Terminal-N,N-Dimethyl-N-(A,S)PK-Serine-[Protein] = S-Adenosyl-L-Homocysteine + N-Terminal-N,N,N-Trimethyl-N-(A,S)PK-[Protein];;(2) 2 S-Adenosyl-L-Methionine + N-Terminal-PPK-[Protein] = 2 S-Adenosyl-L-Homocysteine + N-Terminal-N,N-Dimethyl-N-PPK-[Protein] (Overall Reaction);;(2a) S-Adenosyl-L-Methionine + N-Terminal-PPK-[Protein] = S-Adenosyl-L-Homocysteine + N-Terminal-N-Methyl-N-PPK-[Protein];;(2b) S-Adenosyl-L-Methionine + N-Terminal-N-Methyl-N-PPK-[Protein] = S-Adenosyl-L-Homocysteine + N-Terminal-N,N-Dimethyl-N-PPK-[Protein]，系统名称为S-Adenosyl-L-Methionine:N-Terminal-(A,P,S)PK-[Protein] Methyltransferase，该酶在起始 L-甲硫氨酸被切除后，甲基化含有 N 端基序 [Ala/Pro/Ser]-Pro-Lys 的靶蛋白的 N 端。当末端氨基酸为 L-脯氨酸时，该酶催化其 α-氨基的两个连续甲基化。当第一个氨基酸为 L-丙氨酸或 L-丝氨酸时，该酶催化三个连续甲基化。
第 2-3 位的 Pro-Lys 不能被其他氨基酸替换 [1,2]。
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