产品内容
本酶催化的反应为2 S-Adenosyl-L-Methionine + [Protein]-L-Arginine = 2 S-Adenosyl-L-Homocysteine + [Protein]-Nomega,Nomega'-Dimethyl-L-Arginine (Overall Reaction);;(1a) S-Adenosyl-L-Methionine + [Protein]-L-Arginine = S-Adenosyl-L-Homocysteine + [Protein]-Nomega-Methyl-L-Arginine;;(1b) S-Adenosyl-L-Methionine + [Protein]-Nomega-Methyl-L-Arginine = S-Adenosyl-L-Homocysteine + [Protein]-Nomega,Nomega'-Dimethyl-L-Arginine，系统名称为S-Adenosyl-L-Methionine:[protein]-L-Arginine N-Methyltransferase ([Protein]-Nomega,Nomega'-Dimethyl-L-Arginine-Forming)，该酶催化对蛋白内精氨酸残基末端胍基氮原子之一的甲基化，形成单甲基精氨酸，随后对第二个末端氮原子甲基化，形成对称二甲基精氨酸。哺乳动物的该酶在细胞核和细胞质中均有活性，通过甲基化某些小核核糖核蛋白在snRNP核心颗粒的组装中发挥作用。参见 EC 2.1.1.319，I型蛋白精氨酸甲基转移酶，EC 2.1.1.321，III型蛋白精氨酸甲基转移酶，及 EC 2.1.1.322，IV型蛋白精氨酸甲基转移酶。
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