产品内容
本酶催化的反应为3 S-Adenosyl-L-Methionine + A [Histone H3]-L-Lysine4 = 3 S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6,N6-Trimethyl-L-Lysine4 (Overall Reaction);;(1a) S-Adenosyl-L-Methionine + A [Histone H3]-L-Lysine4 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6-Methyl-L-Lysine4;;(1b) S-Adenosyl-L-Methionine + A [Histone H3]-N6-Methyl-L-Lysine4 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6-Dimethyl-L-Lysine4;;(1c) S-Adenosyl-L-Methionine + A [Histone H3]-N6,N6-Dimethyl-L-Lysine4 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6,N6-Trimethyl-L-Lysine4，系统名称为S-Adenosyl-L-Methionine:[histone H3]-L-Lysine4 N6-Trimethyltransferase，该条目描述多种连续甲基化组蛋白 H3 的 L-赖氨酸4 残基（H3K4）、最终生成三甲基化形式的酶。这些修饰影响染色质相关蛋白的结合。在大多数情况下，该位置的三甲基化与基因激活相关。EC 2.1.1.364（[组蛋白 H3]-赖氨酸4 N-甲基转移酶）描述只能催化该底物单甲基化（本条目的第一个子反应）的酶；EC 2.1.1.370（[组蛋白 H3]-赖氨酸4 N-二甲基转移酶）描述只催化该底物二甲基化（本条目的前两个子反应）的酶。
![天净沙[组蛋白H3]-赖氨酸(4)N-三甲基转移酶活性测定试剂盒产品图片](https://www.tjs.bio/content/xtheme/tianjingsha/images/noimage.jpg)
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