产品内容
本酶催化的反应为3 S-Adenosyl-L-Methionine + A [Histone H3]-L-Lysine9 = 3 S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6,N6-Trimethyl-L-Lysine9 (Overall Reaction);;(1a) S-Adenosyl-L-Methionine + A [Histone H3]-L-Lysine9 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6-Methyl-L-Lysine9;;(1b) S-Adenosyl-L-Methionine + A [Histone H3]-N6-Methyl-L-Lysine9 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6-Dimethyl-L-Lysine9;;(1c) S-Adenosyl-L-Methionine + A [Histone H3]-N6,N6-Dimethyl-L-Lysine9 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6,N6-Trimethyl-L-Lysine9,系统名称为S-Adenosyl-L-Methionine:[histone H3]-L-Lysine9 N6-Trimethyltransferase,该条目描述多种连续甲基化组蛋白 H3 的 L-赖氨酸9 残基(H3K9)、最终生成三甲基化形式的酶。这些修饰影响染色质相关蛋白的结合。一般来说,H3K9 的甲基化导致受影响靶基因的转录抑制。参见 EC 2.1.1.367([组蛋白 H3]-赖氨酸9 N-甲基转移酶)、EC 2.1.1.368([组蛋白 H3]-赖氨酸9 N-二甲基转移酶)和 EC 2.1.1.366([组蛋白 H3]-N6,N6-二甲基-赖氨酸9 N-甲基转移酶)。