产品内容
本酶催化的反应为3 S-Adenosyl-L-Methionine + A [Histone H3]-L-Lysine27 = 3 S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6,N6-Trimethyl-L-Lysine27 (Overall Reaction);;(1a) S-Adenosyl-L-Methionine + A [Histone H3]-L-Lysine27 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6-Methyl-L-Lysine27;;(1b) S-Adenosyl-L-Methionine + A [Histone H3]-N6-Methyl-L-Lysine27 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6-Dimethyl-L-Lysine27;;(1c) S-Adenosyl-L-Methionine + A [Histone H3]-N6,N6-Dimethyl-L-Lysine27 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6,N6-Trimethyl-L-Lysine27，系统名称为S-Adenosyl-L-Methionine:[histone H3]-L-Lysine27 N6-Trimethyltransferase，该条目描述连续甲基化组蛋白 H3 的 L-赖氨酸27 残基（H3K27）、最终生成三甲基化形式的酶。这些修饰影响染色质相关蛋白的结合。赖氨酸27 的甲基化导致受影响靶基因的转录抑制。该酶与其他蛋白结合形成对活性至关重要的复合体。该酶也可以甲基化一些非组蛋白。参见 EC 2.1.1.369（[组蛋白 H3]-赖氨酸27 N-甲基转移酶）和 EC 2.1.1.371（[组蛋白 H3]-赖氨酸27 N-二甲基转移酶）。
![天净沙[组蛋白H3]-赖氨酸27 N-三甲基转移酶活性测定试剂盒产品图片](https://www.tjs.bio/content/xtheme/tianjingsha/images/noimage.jpg)
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