产品内容
本酶催化的反应为3 S-Adenosyl-L-Methionine + A [Histone H3]-L-Lysine36 = 3 S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6,N6-Trimethyl-L-Lysine36 (Overall Reaction);;(1a) S-Adenosyl-L-Methionine + A [Histone H3]-L-Lysine36 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6-Methyl-L-Lysine36;;(1b) S-Adenosyl-L-Methionine + A [Histone H3]-N6-Methyl-L-Lysine36 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6-Dimethyl-L-Lysine36;;(1c) S-Adenosyl-L-Methionine + A [Histone H3]-N6,N6-Dimethyl-L-Lysine36 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6,N6-Trimethyl-L-Lysine36，系统名称为S-Adenosyl-L-Methionine:[histone H3]-L-Lysine36 N6-Trimethyltransferase，该酶源自酵母和哺乳动物，催化组蛋白 H3 赖氨酸36（H3K36）的连续甲基化，形成三甲基化形式。这些修饰影响染色质相关蛋白的结合。该酶通过与 RNA 聚合酶 II 大亚基的相互作用将甲基化反应与转录延伸偶联。参见 EC 2.1.1.357，[组蛋白 H3]-赖氨酸36 N-二甲基转移酶。
![天净沙[组蛋白H3]-赖氨酸36 N-三甲基转移酶活性测定试剂盒产品图片](https://www.tjs.bio/content/xtheme/tianjingsha/images/noimage.jpg)
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