产品内容
本酶催化的反应为2 S-Adenosyl-L-Methionine + A [Histone H3]-L-Lysine9 = 2 S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6-Dimethyl-L-Lysine9 (Overall Reaction);;(1a) S-Adenosyl-L-Methionine + A [Histone H3]-L-Lysine9 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6-Methyl-L-Lysine9;;(1b) S-Adenosyl-L-Methionine + A [Histone H3]-N6-Methyl-L-Lysine9 = S-Adenosyl-L-Homocysteine + A [Histone H3]-N6,N6-Dimethyl-L-Lysine9,系统名称为S-Adenosyl-L-Methionine:[histone H3]-L-Lysine9 N6-Dimethyltransferase,本条描述若干种从植物中鉴定的酶,它们将组蛋白 H3 的 L-赖氨酸-9 残基(H3K9)连续甲基化两次,最终生成二甲基化形式。这些修饰影响染色质相关蛋白的结合。一般而言,H3K9 的甲基化会导致受影响靶基因的转录抑制。参见 EC 2.1.1.367([组蛋白 H3]-赖氨酸9 N-甲基转移酶)、EC 2.1.1.366([组蛋白 H3]-N6,N6-二甲基-赖氨酸9 N-甲基转移酶)和 EC 2.1.1.355([组蛋白 H3]-赖氨酸9 N-三甲基转移酶)。