产品内容
本酶催化的反应为3 S-Adenosyl-L-Methionine + A [Histone H4]-L-Lysine20 = 3 S-Adenosyl-L-Homocysteine + A [Histone H4]-N6,N6,N6-Trimethyl-L-Lysine20 (Overall Reaction);;(1a) S-Adenosyl-L-Methionine + A [Histone H4]-L-Lysine20 = S-Adenosyl-L-Homocysteine + A [Histone H4]-N6-Methyl-L-Lysine20;;(1b) S-Adenosyl-L-Methionine + A [Histone H4]-N6-Methyl-L-Lysine20 = S-Adenosyl-L-Homocysteine + A [Histone H4]-N6,N6-Dimethyl-L-Lysine20;;(1c) S-Adenosyl-L-Methionine + A [Histone H4]-N6,N6-Dimethyl-L-Lysine20 = S-Adenosyl-L-Homocysteine + A [Histone H4]-N6,N6,N6-Trimethyl-L-Lysine20;;系统名称为S-Adenosyl-L-Methionine:[histone H4]-L-Lysine20 N6-Trimethyltransferase，该酶从裂殖酵母粟酒裂殖酵母（Schizosaccharomyces pombe）中鉴定，催化组蛋白 H4 的 L-赖氨酸-20 残基（H4K20）三次连续甲基化，生成三甲基化形式。该位点的甲基化显然不参与基因表达调控或异染色质功能，但参与 DNA 损伤应答。参见 EC 2.1.1.361（[组蛋白 H4]-赖氨酸20 N-甲基转移酶）和 EC 2.1.1.362（[组蛋白 H4]-N-甲基-L-赖氨酸20 N-甲基转移酶）。
![天净沙[组蛋白H4]-赖氨酸20 N-三甲基转移酶活性测定试剂盒产品图片](https://www.tjs.bio/content/xtheme/tianjingsha/images/noimage.jpg)
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