本酶催化的反应为(1) DNA (Containing 6-O-Methylguanine) + Protein L-Cysteine = DNA (Without 6-O-Methylguanine) + Protein S-Methyl-L-Cysteine;;(2) DNA (Containing 4-O-Methylthymine) + Protein L-Cysteine = DNA (Without 4-O-Methylthymine) + Protein S-Methyl-L-Cysteine，系统名称为DNA-6-O-Methylguanine/DNA-4-O-Methylthymine:[protein]-L-Cysteine S-Methyltransferase，该蛋白参与甲基化DNA的修复。与去除甲基化碱基留下脱嘌呤/脱嘧啶位点的EC 3.2.2.20（DNA-3-甲基腺嘌呤糖苷酶I）和EC 3.2.2.21（DNA-3-甲基腺嘌呤糖苷酶II）不同，该酶将甲基从甲基化DNA转移到内部半胱氨酸残基，留下完整的核苷酸。由于甲基转移是不可逆的，该酶只能催化单次周转。
![天净沙甲基化DNA-[蛋白质]-半胱氨酸 S-甲基转移酶活性测定试剂盒产品图片](https://www.tjs.bio/content/xtheme/tianjingsha/images/noimage.jpg)
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