本酶催化的反应为(1) Acetyl-CoA + An N-Terminal-Glycyl-[Protein] = An N-Terminal-Nalpha-Acetyl-Glycyl-[Protein] + CoA;;(2) Acetyl-CoA + An N-Terminal-L-Alanyl-[Protein] = An N-Terminal-Nalpha-Acetyl-L-Alanyl-[Protein] + CoA;;(3) Acetyl-CoA + An N-Terminal-L-Seryl-[Protein] = An N-Terminal-Nalpha-Acetyl-L-Seryl-[Protein] + CoA;;(4) Acetyl-CoA + An N-Terminal-L-Valyl-[Protein] = An N-Terminal-Nalpha-Acetyl-L-Valyl-[Protein] + CoA;;(5) Acetyl-CoA + An N-Terminal-L-Cysteinyl-[Protein] = An N-Terminal-Nalpha-Acetyl-L-Cysteinyl-[Protein] + CoA;;(6) Acetyl-CoA + An N-Terminal-L-Threonyl-[Protein] = An N-Terminal-Nalpha-Acetyl-L-Threonyl-[Protein] + CoA，系统名称为Acetyl-CoA:N-Terminal-Gly/Ala/Ser/Val/Cys/Thr-[Protein] Nalpha-Acetyltransferase，N端乙酰转移酶（NAT）催化将来自乙酰-CoA的乙酰基共价连接到蛋白N末端的游离α-氨基上。这种不可逆修饰中和了N末端的正电荷，使N末端残基变大且更具疏水性。NatA复合体存在于所有真核生物中，专一靶向起始甲硫氨酸被去除后暴露的N末端Ala、Gly、Cys、Ser、Thr和Val残基。
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