产品内容
本酶催化的反应为[Protein]-N6-Acetyl-L-Lysine + NAD+ + H2O = [Protein]-L-Lysine + 2''-O-Acetyl-ADP-D-Ribose + Nicotinamide (Overall Reaction);;(1a) [Protein]-N6-Acetyl-L-Lysine + NAD+ = [Protein]-N6-[1,1-(5-Adenosylyl-alpha-D-Ribose-1,2-Di-O-Yl)ethyl]-L-Lysine + Nicotinamide;;(1b) [Protein]-N6-[1,1-(5-Adenosylyl-alpha-D-Ribose-1,2-Di-O-Yl)ethyl]-L-Lysine + H2O = [Protein]-L-Lysine + 2''-O-Acetyl-ADP-D-Ribose，系统名称为[Protein]-N6-Acetyl-L-Lysine:NAD+ N-Acetyltransferase (NAD+-Hydrolysing; 2''-O-Acetyl-ADP-D-Ribose-Forming)，该酶存在于所有生命领域中，通过使蛋白质脱乙酰化参与基因调控。部分 2''-O-乙酰基-ADP-D-核糖非酶促地转化为 3''-O-乙酰基-ADP-D-核糖。
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