Name: 天净沙[核糖体蛋白US12](天冬氨酸89-C3)-甲基硫转移酶活性测定试剂盒
Brand: 天净沙
SKU: 7-EC2.8.4.4
Availability: InStock

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天净沙[核糖体蛋白US12](天冬氨酸89-C3)-甲基硫转移酶活性测定试剂盒

英文名：Skygen [Ribosomal Protein US12] (Aspartate89-C3)-Methylthiotransferase Assay Kit

别名：RimO; [Ribosomal Protein S12]-Asp89:sulfur-(Sulfur Carrier),S-Adenosyl-L-Methionine C3-Methylthiotransferase; [Ribosomal Protein S12]-L-Aspartate89:sulfur-(Sulfur Carrier),S-Adenosyl-L-Methionine C3-Methylthiotransferase

产品编号：7-EC2.8.4.4

保存温度：-20℃

运输温度：Cold

货号

规格

货期

目录价

7-EC2.8.4.4

100 T

3-4 Weeks

本酶催化的反应为L-Aspartate89-[Ribosomal Protein US12] + Sulfur-(Sulfur Carrier) + 2 S-Adenosyl-L-Methionine + Reduced Acceptor = 3-(Methylsulfanyl)-L-Aspartate89-[Ribosomal Protein US12] + S-Adenosyl-L-Homocysteine + (Sulfur Carrier) + L-Methionine + 5'-Deoxyadenosine + Oxidized Acceptor (Overall Reaction);; (1A) S-Adenosyl-L-Methionine + L-Aspartate89-[Ribosomal Protein US12] + Sulfur-(Sulfur Carrier) = S-Adenosyl-L-Homocysteine + L-Aspartate89-[Ribosomal Protein US12]-Methanethiol + (Sulfur Carrier);; (1B) L-Aspartate89-[Ribosomal Protein US12]-Methanethiol + S-Adenosyl-L-Methionine + Reduced Acceptor = 3-(Methylsulfanyl)-L-Aspartate89-[Ribosomal Protein US12] + L-Methionine + 5'-Deoxyadenosine + Oxidized Acceptor，系统名称为[Ribosomal Protein US12]-L-Aspartate89:sulfur-(Sulfur Carrier),S-Adenosyl-L-Methionine C3-(Methylsulfanyl)transferase，这种细菌酶结合两个 [4Fe-4S] 簇 [2,3]。两个 [4Fe-4S] 簇的游离铁原子之间形成由五个硫原子构成的桥 [6]。第一个反应中，该酶将AdoMet的甲基转移到硫桥的外部硫离子上。第二个反应中，该酶催化第二分子AdoMet的还原性断裂，生成5'-脱氧腺苷自由基，后者进攻多硫化物桥上被甲基化的硫原子，导致甲硫基转移到天冬氨酸89上 [5,6]。该酶属于依赖S-腺苷-L-甲硫氨酸的自由基（radical AdoMet）酶超家族。

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天净沙[核糖体蛋白US12](天冬氨酸89-C3)-甲基硫转移酶活性测定试剂盒

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天净沙[核糖体蛋白US12](天冬氨酸89-C3)-甲基硫转移酶活性测定试剂盒

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