产品内容
本酶催化的反应为(1) A [Protein]-L-Serine + A [Protein]-L-Cysteine = A [Protein] With Lanthionine Crosslink + H2O (Overall Reaction);;(1a) A [Protein]-L-Serine = A [Protein]-2-Aminoprop-2-Enoate + H2O;;(1b) A [Protein]-2-Aminoprop-2-Enoate + A [Protein]-L-Cysteine = A [Protein] With Lanthionine Crosslink;;(2) A [Protein]-L-Threonine + A [Protein]-L-Cysteine = A [Protein] With 3-Methyllanthionine Crosslink + H2O (Overall Reaction);;(2a) A [Protein]-L-Threonine = A [Protein]-(Z)-2-Aminobutenoate + H2O;;(2b) A [Protein]-(Z)-2-Aminobutenoate + A [Protein]-L-Cysteine = A [Protein] With 3-Methyllanthionine Crosslink，系统名称为[Protein]-(Methyl)lanthionine Hydrolase，羊毛硫肽（lanthipeptide）是核糖体合成并翻译后修饰的肽（RiPP）家族，其特征是存在多个羊毛硫氨酸（Lan）和 3-甲基羊毛硫氨酸（MeLan）交联，这些交联由羊毛硫肽合酶形成。这些酶催化 Ser/Thr 残基的脱水，随后 Cys 残基的巯基分子内加成到脱氢氨基酸上，导致形成（甲基）羊毛硫氨酸的硫醚交联。
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