产品内容
本酶催化的反应为Hydrolysis Of Peptides Of At Least Six Residues, With Bulky Hydrophobic Residues In The P1' Position. Shows A Preference For Hydrophobic Doublets Such As -Phe!Phe- And -Phe!Leu- In Somatostatin-(1-14)-Peptide And Dynorphin A-(1-6)-Peptide, Respectively,一种100 kDa内肽酶,从两栖动物非洲爪蟾(Xenopus laevis)的皮肤分泌。在对1 μM卡托普利不敏感方面类似neprilysin,但对thiorphan(1 μM)不敏感且不能消化[Met5]脑啡肽、[Leu5]脑啡肽、催产素和P物质-(7-11)-肽,这又不同于neprilysin。人神经母细胞瘤细胞中也发现类似的内肽酶 [2]。