产品内容
本酶催化的反应为Cleaves Several Transcription Factors That Are Type-2 Transmembrane Proteins Within Membrane-Spanning Domains. Known Substrates Include Sterol Regulatory Element-Binding Protein (SREBP) -1, SREBP-2 And Forms Of The Transcriptional Activator ATF6. SREBP-2 Is Cleaved At The Site DRSRILL483!CVLTFLCLSFNPLTSLLQWGGA, In Which The Membrane-Spanning Segment Is Underlined. The Residues NP (Bold), 11 Residues Distal To The Site Of Cleavage In The Membrane-Spanning Domain, Are Important For Cleavage By S2P Endopeptidase. Replacement Of Either Of These Residues Does Not Prevent Cleavage, But There Is No Cleavage If Both Of These Residues Are Replaced.肽酶家族M50的典型代表。转录因子SREBP-1和-2合成为附着于内质网膜的前体蛋白，需要两次切割才能释放活性因子，使其能够移动到细胞核。该酶切割第二次切割，因此是"位点2蛋白酶"S2P。
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