产品内容
本酶催化的反应为(1) Tobramycin + Carbamoyl Phosphate + ATP + H2O = Nebramycin 5' + AMP + Diphosphate + Phosphate (Overall Reaction);;(1a) Carbamoyl Phosphate + ATP + H2O = Diphosphate + O-Carbamoyladenylate + Phosphate;;(1b) O-Carbamoyladenylate + Tobramycin = AMP + Nebramycin 5' ;;(2) Kanamycin A + Carbamoyl Phosphate + ATP + H2O = 6''-O-Carbamoylkanamycin A + AMP + Diphosphate + Phosphate (Overall Reaction);;(2a) Carbamoyl Phosphate + ATP + H2O = Diphosphate + O-Carbamoyladenylate + Phosphate;;(2b) O-Carbamoyladenylate + Kanamycin A = AMP + 6''-O-Carbamoylkanamycin A，系统名称为Tobramycin:carbamoyl Phosphate Ligase (AMP,phosphate-Forming)，需要Fe(III)。来自细菌暗色链霉菌 Streptoalloteichus tenebrarius 的该酶催化氨基甲酰磷酸活化生成O-氨基甲酰腺苷酸，随后对卡那霉素和妥布霉素进行氨基甲酰化。
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