产品内容
本酶催化的反应为2 ATP + 2 3-(4-Hydroxyphenyl)pyruvate = 2 AMP + 2 Diphosphate + Atromentin (Overall Reaction);;(1a) ATP + 3-(4-Hydroxyphenyl)pyruvate + [Atromentin Synthase] = AMP + Diphosphate + 3-(4-Hydroxyphenyl)pyruvoyl-[Atromentin Synthase];;(1b) ATP + 3-(4-Hydroxyphenyl)pyruvate + 3-(4-Hydroxyphenyl)pyruvoyl-[Atromentin Synthase] = AMP + Diphosphate + Atromentin + [Atromentin Synthase],系统名称为3-(4-Hydroxyphenyl)pyruvate:3-(4-Hydroxyphenyl)pyruvate Ligase (Atromentin-Forming),需要 Mg2+。该酶存在于某些真菌中,如牛肝菌目和散囊菌目的成员,是一种非核糖体肽合酶样酶,包含三个结构域——腺苷酰化(A)结构域、酰基载体蛋白(ACP)结构域和硫酯酶(TE)结构域。该酶通过腺苷酰化激活 3-(4-羟基苯基)丙酮酸,并催化两个此类分子的二聚化/环化以形成 atromentin。Atromentin 是真菌产生的多种代谢物的前体,包括 pulp 酸(pulvinic acids)和 2,5-二芳基环戊烯酮。